' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 87 Researches
7.5
USERS' SCORE
Good
Based on 33 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
9.5
Bifidobacterium bifidum improves IBS symptoms
Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study.
Significant findings with practical implications
We assessed how Bifidobacterium bifidum MIMBb75 impacts symptoms of irritable bowel syndrome (IBS) in a controlled study of 122 participants.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Read More
9.5
CECT 7347 reduces IBS-D symptoms
A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome.
Highly relevant clinical findings
A randomized, double-blind, placebo-controlled trial exploring CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) revealed promising results for diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
Read More
9
Effective treatment for IBS-C
Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial.
High relevance to IBS research
We aimed to understand how Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) affects irritable bowel syndrome with constipation (IBS-C) through a thorough study. In a randomized, double-blind trial, 30 participants took either RH 3201 or a placebo for 8 weeks.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Those taking RH 3201 experienced significant improvements, including fewer bowel discomforts and reduced bloating issues. We also observed an increase in certain beneficial gut bacteria and a link between specific metabolites and symptom relief. Overall, RH 3201 shows promise as an effective treatment for IBS-C.
Read More
Most Useful Reviews
9.5
Satisfying improvement
I’ve tried numerous probiotic strains, and this product has greatly improved my health, notably reducing my irritable bowel syndrome symptoms. My discomfort from bloating and constipation has vanished, and I feel more absorbed with my food. The capsules don’t require refrigeration, and the ingredients are pure and vegan-friendly, making them suitable for vegetarians. I particularly appreciate the inclusion of Saccharomyces Boulardii, which research suggests is effective for irritable bowel syndrome.
Read More
8.8
Initial discomfort
I experienced symptoms akin to irritable bowel syndrome while taking this probiotic. Initially, I suffered from headaches and nausea but, after a week, these symptoms subsided. Now, I'm feeling great, and my intestinal issues have significantly improved. I'm satisfied with the results and plan to continue using it in cycles.
Read More
9.5
Saved from gastric issues
Best decision I ever made! I've been taking this probiotic for years, saving me from gastric turmoil and well-meaning but clueless 'specialists'. Diagnosed with a 'spastic colon' or irritable bowel syndrome (IBS), I refused medications they prescribed for life. I eliminated my trigger foods and found the Garden of Life line, taking it ever since. No more nagging discomfort or severe stomach pains, and I put my mom on it too when her doctors suggested complicated regimens; she's doing much better now.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 87 Researches
7.5
9.5
Effective probiotic IBS treatment
Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial.
High relevance for IBS management
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9.5
Effective probiotic IBS treatment
Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial.
High relevance for IBS management
This randomized, single-blinded trial evaluated the impact of probiotics, specifically Lactobacillus acidophilus and plantarum, on patients with diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
We found that when added to standard IBS treatment, these probiotics significantly improved symptoms over a 12-week period.
Group B, the probiotic group, experienced better results, including fewer days with pain and greater satisfaction with bowel habits. While both groups saw reductions in IBS severity, the probiotics led to complete remission in many patients, which is promising for future treatment guidelines.
Read More
9.5
Bifidobacterium bifidum improves IBS symptoms
Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study.
Significant findings with practical implications
We assessed how Bifidobacterium bifidum MIMBb75 impacts symptoms of irritable bowel syndrome (IBS) in a controlled study of 122 participants.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Over four weeks, those taking MIMBb75 reported significantly reduced IBS symptoms compared to the placebo group.
With many experiencing better pain relief and improved quality of life, these findings suggest that MIMBb75 could be a valuable treatment option for IBS, showing durability with minimal side effects.
Read More
9.5
CECT 7347 reduces IBS-D symptoms
A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome.
Highly relevant clinical findings
A randomized, double-blind, placebo-controlled trial exploring CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) revealed promising results for diarrhea-predominant irritable bowel syndrome (IBS-D).
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
We found that after 12 weeks, both ES1 and HT-ES1 significantly reduced symptom severity compared to a placebo, as shown by lower IBS-Symptom Severity Scale scores.
Other improvements included better stool consistency and quality of life. This study marks a breakthrough with the first positive findings for a probiotic or postbiotic from this strain specifically for IBS-D patients.
Read More
9
Lactobacillus drink benefits IBS-C
Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink.
High relevance for IBS treatment
We explored the impact of a Lactobacillus-containing cultured milk drink on individuals with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, participants consumed this drink daily while we assessed their clinical symptoms and inflammatory markers.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Impressively, 97.4% reported improvement in symptoms, along with noticeable reductions in intestinal transit time and fecal pH. Evidence also showed lowered levels of pro-inflammatory cytokines in IBS-C participants, supporting potential adjunctive benefits of this treatment for IBS-C patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 33 Reviews
8.4
9.5
Satisfying improvement
I’ve tried numerous probiotic strains, and this product has greatly improved my health, notably reducing my irritable bowel syndrome symptoms. My discomfort from bloating and constipation has vanished, and I feel more absorbed with my food. The capsules don’t require refrigeration, and the ingredients are pure and vegan-friendly, making them suitable for vegetarians. I particularly appreciate the inclusion of Saccharomyces Boulardii, which research suggests is effective for irritable bowel syndrome.
Read More
9.5
Stabilised digestion
I needed a good probiotic after gallbladder surgery, and this product did not disappoint. After researching various options, I've now been taking it for two weeks and my gastrointestinal health has stabilised. Symptoms of irritable bowel syndrome, such as bloating, have disappeared. I recommend it for anyone needing digestive support.
Read More
9.5
Effective results
Primal Defence Ultra is superior to other probiotics I've tried. Its diverse bacterial strains yield significant improvements in addressing my irritable bowel syndrome symptoms, enhancing digestion and mood. While it is pricier, the benefits justify the cost.
9.5
Digestive relief
Great! I have been using this probiotic for several years and find it to be the best available. It effectively assists with my digestive issues, bloating, and bowel movements. I take one capsule at night after meals. I highly recommend it.
9.5
Skin condition improved
This probiotic has really helped my skin issues, which were previously quite severe. I’ve noticed a significant decrease in flare-ups, and my bowels have normalised, largely alleviating my irritable bowel syndrome concerns. I wholeheartedly recommend this product!
